Resumo

DORADO BERNAL, Beatriz A. et al. Evaluation of the effectiveness of Quinfamida for the infection of Trichinella spiralis in intestinal phase and in murine model. BIOFARBO [online]. 2011, vol.19, n.1, pp. 28-33. ISSN 1813-5363.

The trichinellosis is a parasitic disease transmitted by nematode Trichinella spiralis. The life cicle of the parasitic includes three stages: the intestinal phase, the parenteral phase and the muscular phase. At the moment the treatment used for the trichinellosis is the administration of albendazol or mebendazol. These medecines have demonstrated to be effective against the parasite, but only if they are administered per prolonged periods. Nevertheless it causes adverse effects in the host. The objective of this work was to evaluate the therapeutic effect of the Quinfamida as treatment for the infection caused by Trichinella spiralis in intestinal phase and in murine model. The study comprised four groups (four Long Evans rats each), the rats were infected and they were dosed at 24h after the infection with a duration of three days of treatment. The obtained results showed that the administration of Quinfamida is not effective to the control of the infection by Trichinella spiralis.

Palavras-chave : Quinfamida; treatment; Trichinella spiralis; intestinal phase.